KMID : 0363320200410061089
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Journal of Korean Oriental Internal Medicine 2020 Volume.41 No. 6 p.1089 ~ p.1099
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A Review of the Neuroprotective Effects of Cinnamon in Experimental Studies on Parkinson¡¯s Disease
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Heo Hye-Min
Han Ju-Hee Jeong Min-Jeong Kim Hong-Jun Jang In-Soo
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Abstract
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Objective: The purpose of this study was to investigate the effect of cinnamon on the treatment of Parkinson¡¯s disease (PD) and to introduce its use in Korea.
Method: We searched the experimental studies in electronic databases (PubMed, CNKI, Wanfang, CiNii, J-STAGE, Science ON, and OASIS) using the key search terms ¡°cinnamic acid¡±, ¡°cinnamon¡±, ¡°cinnamomum¡±, ¡°Parkinson¡¯s disease¡±, ¡°Parkinson disease¡±, ¡°Parkinsonism¡±, and ¡°dopamine¡±. This study only involved experimental studies (in vivo and in vitro) that adopted cinnamon as a single administration and measured indicators relating to Parkinson¡¯s disease, including parkin, tyrosine hydroxylase (TH), and dopamine.
Results: A Total of 11 literature studies were selected, and they all showed that treatment with cinnamon has a neuroprotective effect. Cinnamon activated neuroprotective factors and restored neurotransmitters and it reduced the rate of oxidative stress and inflammation in neurons. As a result, cell viability was upregulated, while cell apoptosis and neurodegeneration were downregulated. Five in vivo studies, through behavioral tests, also confirmed that cinnamon recovers locomotor function in PD models.
Conclusion: We identified that cinnamon is an effective neural protector and improves motor performance in behavioral testing in the experimental PD studies.
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KEYWORD
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cinnamon, Parkinson¡¯s disease, dopamine, review
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